Apicomplexan Parasites Molecular Approaches toward Targeted Drug Development
by Becker, Katja; Selzer, Paul M.Buy New
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Summary
Author Biography
Table of Contents
| Foreword | p. v |
| Preface | p. xi |
| List of Contributors | p. xiii |
| Screening, Bioinformatics, Chemoinformatics, and Drug Design | p. 1 |
| Drug Discovery Approaches Toward Anti Parasitic Agents | p. 3 |
| New Bioinformatic Strategies Against Apicomplexan Parasites | p. 21 |
| Sorting Potential Therapeutic Targets in Apicompiexa | p. 35 |
| Alternatives to Drug Development in the Apicompiexa | p. 53 |
| Metabolic Pathways and Processes Addressed by Current Drug Discovery Approaches | p. 75 |
| Energy Metabolism as an Antimalarial Drug Target | p. 77 |
| Polyamines in Apicomplexan Parasites | p. 97 |
| The Reducing Milieu of Parasitized Cells as a Target of Antimalarial Agents: Methylene Blue as an Ethical Drug | p. 225 |
| Lipids as Drug Targets for Malaria Therapy | p. 137 |
| Targeting Apicoplast Pathways in Plasmodium | p. 163 |
| Lipoic Acid Acquisition and Glutathione Biosynthesis in Apicomplexan Parasites | p. 287 |
| Antimalarial Drugs and Molecules Inhibiting Hemozoin Formation | p. 205 |
| Exploiting the Vitamin Metabolism of Apicomplexa as Drug Targets | p. 235 |
| Vitamin Biosynthetic Pathways, the PLP Synthase Complex, and the Potential for Targeting Protein-Protein Interaction | p. 251 |
| Targeting Prokaryotic Enzymes in the Eukaryotic Pathogen Cryptosporidium | p. 271 |
| Drug Targets in Apicomplexan Parasites | p. 287 |
| Novel Apicomplexan Phosphatases and Immunophilins as Domain Specific Drug Targets | p. 289 |
| Dehydrogenases and Enzymes of the Mitochondrial Electron Transport Chain as Anti-Apicomplexan Drug Targets | p. 307 |
| Calcium Dependent Protein Kinases as Drug Targets in Apicomplexan Parasites | p. 319 |
| Protein Acylation: New Potential Targets for Intervention Against the Apicomplexa | p. 335 |
| Drugs and Drug Targets in Neospora caninum and Related Apicomplexans | p. 359 |
| Compounds | p. 373 |
| Subversive Substrates of Glutathione Reductases from Plasmodium falciparum-Infected Red Blood Cells as Antimalarial Agents | p. 375 |
| Ferroquine: A Concealed Weapon | p. 397 |
| Current Aspects of Endoperoxides in Antiparasitic Chemotherapy | p. 413 |
| Plasmodium Hsp90 as an Antimalarial Target | p. 431 |
| Drug Discovery Against Babesia and Toxoplasma | p. 453 |
| Search for Drugs and Drug Targets against Babesia bovis, Babesia bigemina, Babesia caballi, and Babesia (Theileria) equi | p. 469 |
| Orlistat: A Repositioning Opportunity as a Growth Inhibitor of Apicomplexan Parasites? | p. 482 |
| Recent Drug Discovery Against Cryptosporidium | p. 493 |
| Index | p. 523 |
| Table of Contents provided by Ingram. All Rights Reserved. |
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